Digital Research Unit at the Faculty of Dentistry Achieves First External Research Milestone with Publication of a Rare Case Report on Dental Implant Rehabilitation
Researchers from the Digital Research Unit at the Faculty of Dentistry, International Private University for Sciences and Technology, have published a clinical case report titled:
“Dental Implant Rehabilitation for a Patient with Primary Hyperoxaluria Type 1: A 14-Month Case Report.” The study appeared in *BMC Oral Health*—a Q1-ranked journal published by Springer Nature and indexed in Scopus and Web of Science.
This is the first case of its kind globally to document oral rehabilitation using dental implants in a patient with Primary Hyperoxaluria Type 1 (PH1)—a very rare genetic disorder with an estimated incidence of approximately one case per million people.
Primary Hyperoxaluria Type 1 (PH1) is a rare metabolic disorder characterized by oxalate deposition in the body. It can affect bone metabolism through various mechanisms, including oxalate accumulation in the alveolar bone, renal osteodystrophy, and the long-term effects of immunosuppressive therapy following organ transplantation.
Case Presentation and Treatment Plan
The report details the oral rehabilitation—using dental implants—of a patient with a complex medical history resulting from PH1, including a combined liver and kidney transplant and multiple systemic conditions. Given the unsuitability of conventional dental prosthetic options—due to external root resorption and the poor prognosis of the remaining teeth—dental implant therapy was selected following a comprehensive clinical and radiographic assessment.
Six months later, resonance frequency analysis demonstrated secondary implant stability, with Implant Stability Quotient (ISQ) values of 75 on the right side and 74 on the left.
Clinical and radiographic evaluation at the 14-month mark further revealed stable peri-implant conditions, with no notable complications observed.
Conclusion
This case suggests that dental implants may represent a viable treatment option for select patients with primary hyperoxaluria type I, provided there is a comprehensive risk assessment, an individualized treatment plan, and close postoperative follow-up.
However, the findings are limited by the fact that this report covers only a single case and a relatively short follow-up period; consequently, the results should be interpreted as preliminary hypotheses rather than definitive evidence regarding long-term dental implant outcomes in this patient population.